EUROPAD Addiction Journal

Heroin Addiction and Related Clinical Problems, the official journal of EUROPAD (European Opiate Addiction Treatment Association), is a peer-reviewed publication for professionals wanting to stay informed of research and opinion on opioid misuse treatment in Europe and around the world. A particular emphasis is on medication-assisted treatments for opioid addiction, particularly methadone. Full copies of the journal, dating back to its inception in 1999, are available here for free download as PDF documents. These are listed in descending order with the most current year and editions at the top.

2008 2007 2006 2005 2004 2003 2002 2001 2000 1999

2009

Heroin Addiction and Related Clinical Problems. 2009(December), Vol. 11, No.4

QT Interval
Psychoactive Drugs and Prolongation of the QT Interval
Opioid Treatment and “Long-QT Syndrome (LQTS)”: a Critical Review of the Literature
Management of Cardiac Risk during Methadone Treatment: Focus on the QT Interval

Cardiovascular Complications of Cocaine Use

Download PDF: <HeroinAdd11-4.pdf> (1.1 MB, 44pp)

Heroin Addiction and Related Clinical Problems. 2009(September), Vol. 11, No.3

Methadone Treatment in Italy in the Third Millennium: Continuing Fear of Treatment
Pharmacology and Neurochemistry of Methadone
Cannabis and Premonitory Symptoms of Schizophrenia: What Is the Time Sequence?
Alcoholics With a History of Heroin Consumption: Clinical Features and Chronology of Substance Abuse
Opioid Dependence and Quality of Life: Changes in the Heroin Epidemic
Predictors for Non-Relapsing in Methadone- and Buprenorphine-maintained Heroin Addicts: A Comparative Study
Echoing the Patient’s Lack of Insight: A Role We Must Avoid Playing
Download PDF: <HeroinAdd11-3.pdf> (1.4 MB, 52pp)

Heroin Addiction and Related Clinical Problems. 2009(June), Vol. 11, No.2

Swedish Use and Misuse of the Dole & Nyswander Treatment
Methadone-treated Patients After Switching to Buprenorphine in Residential Therapeutic Communities: An Addiction-specific Assessment of Quality of Life
Clinical Trial on the Use of Olanzapine in Reducing the Consumption of Cocaine in Methadone Maintenance Programmes
Voices of Experience: Attitudes and Opinions of Recipients of Unsupervised Injectable Opiate Treatment in the Northwest of England
Substitution Therapy. A New Problem of Biomedical Ethics and Medical Law
New Approaches in the Treatment of Opioid Dependency During the Pregnancy
QTc Interval Screening. American Association for the Treatment of Opioid Dependance (AATOD) Policy and Guidance Statement
Download PDF: <HeroinAdd11-2.pdf> (2.07 MB, 68pp)

Heroin Addiction and Related Clinical Problems. 2009(March), Vol. 11, No.1

Treatment of Opioid Dependence and ADHD/ADD with Opioid Maintenance and Central Stimulants
Dihydrocodeine for the Treatment of Alcohol Dependence
Unintentional and Intentional Injuries Due to Opiate Abuse
Use and Abuse of High-Dose Buprenorphine (HDB) Obtained Without a Prescription: a French Survey
A 10-Year Evaluation of Chronic Pain Patients Treated with Opioids
Psychotherapeutic Experiences with Methadone Maintained Patients in the Framework of Multidisciplinary Clinical Institution
Preferences for Buprenorphine/Naloxone (Suboxone®) and Buprenorphine (Subutex®) in Patients Receiving
Buprenorphine Maintenance Therapy in France: A Prospective, Multicentre Study
Coordinating Methadone Treatment Providers and Policymakers: Lessons Learned Over 30 Years
En Route to 90% Retention. ‘Active Rehabilitation’ in Central Norway
Download PDF: <HeroinAdd11-1.pdf> (2.66 MB, 52pp)

2008

Heroin Addiction and Related Clinical Problems. 2008(December), Vol. 10, No.4

Buprenorphine-Naloxone Versus Methadone Maintenance Therapy: A Randomised Double-Blind With Opioid-Dependent Patients
Predictors for Non-Relapsing Status in Methadone Maintained Heroin Addicts. A Long Term Perspective Study
Unintentional and Intentional Injuries Due to Opiate Abuse
Scientific Evidence and Practical Experience with Methadone-Assisted Withdrawal of Heroin-Dependent Pregnant Patients
Opioid Therapy and Restoration of the Immune Function in Heroin-Addicted Patients
Major Policy and Clinical Developments in the Use of Methadone and Buprenorphine Treatment in the U.S.
Download PDF: <HeroinAdd10-4.pdf> (1.59 MB, 52pp)

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Heroin Addiction and Related Clinical Problems. 2008(September), Vol. 10, No.3

When a New Drug Promotes the Integration of Treatment Modalities: Suboxone and Harm Reduction
Pseudo-Addiction: The Illustrative Case of Howard Hughes
The Under Treatment of Pain: A Global Problem. An Educational Approach
Finnish Experience With Buprenorphine-Naloxone Combination (Suboxone®): Survey Evaluations With Intravenous Drug Users
Fifteen Years of Office-Based Prescribing in Croatia. Attitudes, Obstacles and Outcomes
Download PDF: HeroinAdd10-3.pdf <HeroinAdd10-3.pdf> (2.18 MB, 44 pp)
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Heroin Addiction and Related Clinical Problems. 2008(June), Vol. 10, No.2

Evaluation of Therapeutic Alternatives to Imprisonment for Drug-Dependent Offenders. Findings of a Comparative European Multi-country Study
Motivational Interventions for Methadone-Treated Patients
Health Care Utilization and Morbidity Associated With Methadone and Buprenorphine Treatment
GPs’ Office Based Methadone Maintenance Treatment in Trieste, Italy.Therapeutic Efficacy and Predictors of Clinical Response
Use of Sertraline in Depressed Methadone Maintenance Patients
Download PDF: HeroinAdd10-2.pdf <HeroinAdd10-2.pdf> (1.28 MB, 44 pp)
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Heroin Addiction and Related Clinical Problems. 2008(March), Vol. 10, No. 1

Sexual Behaviour of Heroin Addicts in Treatment
First Experience of Opioid Therapy with Buprenorphine in Ukraine
Administration of Nalbuphine to Heroin Addicts. Feasibility and Short-Term Effects
Evidence of Reliability and Validity of the Opiate Dosage Adequacy Scale (ODAS) in a Sample of Methadone Maintenance Patients
Improvement in the Quality of Live in Heroin Addicts: Differences Between Methadone and Buprenorphine Treatment
Methadone: A Fast and Powerful Anti-anxiety, Anti-depressant and Anti-psychotic Treatment
Explaining Agonist Treatment Through Movie Language: The Interesting Allegory of ‘Videodrome’
Download PDF: HeroinAdd10-1.pdf <HeroinAdd10-1.pdf> (2.77 MB, 60 pp) Large File

2007

Heroin Addiction and Related Clinical Problems. 2007(December), Vol. 9, No. 4

Addiction Treatment: When Will Medical Principles Matter?
Maintenance: How Long?
Agonist Opioid Treatment in Prisons
The Need For Patient Education. Opinions And Attitudes On Heroin Addiction
Motivational Interviewing: Linking Systems and Dancing with Clients
Download PDF: HeroinAdd9-4.pdf (1.4 MB, 60 pp)
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Heroin Addiction and Related Clinical Problems. 2007(September), Vol. 9, No. 3

Addiction Treatment: When Will Medical Principles Matter?
New Approaches in the Treatment of Opioid Dependency during Pregnancy
Clinical Features of Heroin Dependence Onset in Young Women
Supporting GP’s in Improving Substitute Prescribing for Opiate Users in the UK
Mortality Among Opiate Abusers in Stockholm: A Longitudinal Study
Methadone Treatment in an Italian Criminal Mental Hospital
Download PDF: HeroinAdd9-3.pdf (1.9 MB, 60 pp)

Heroin Addiction and Related Clinical Problems. 2007(June), Vol. 9, No. 2

Can Heroin Maintenance Treatment Be Called a Therapy?
Brain Disintegration in Heroin Addicts: The Natural Course of the Disease and the Effects of Methadone Treatment
Voucher-Based Reinforcement Therapy for Drug-Dependent Pregnant Women
Pharmacokinetic and Pharmacogenetic Factors Influencing Methadone Plasma Levels
Providing Comprehensive Treatment in Medication Assisted Opioid Treatment: The Development of Needs Based Treatment at a Medical School Sponsored Program
Dihydrocodeine Treatment of Alcohol Addicts With Previous Opiate Addiction — Case Reports
Download PDF: HeroinAdd9-2.pdf (1.04 MB, 68 pp)
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Heroin Addiction and Related Clinical Problems. 2007(March), Vol. 9, No. 1

Effects of Opioid Pharmacotherapy on Psychomotor and Cognitive Performance: A Review of Human Laboratory Studies of Methadone and Buprenorphine
The Vincent P. Dole Research and Treatment Institute for Opiate Dependence: An Integrated Biopsychosocial Model for the Treatment of Methadone Maintained Patients
Opioid Substitution with Methadone and Buprenorphine: Sexual Dysfunction as a Side Effect of Therapy
Paxil (Paroxetine) in Complex Therapy in Heroin Addicts
Use of Sodium Gamma-Hydroxybutyrate (GHB) in Alcoholic Heroin Addicts and Polydrug-Abusers
Download PDF: HeroinAdd9-1.pdf (1.57 MB, 84 pp)

2006

Heroin Addiction and Related Clinical Problems. 2006(Dec), Vol. 8, No. 4

Combating the Stigma: Discarding the Label "Substitution Treatment"
in Favour of "Behaviour-Normalization Treatment"
In the Service of Patients: The Legacy of Dr. Dole
Injecting Buprenorphine Tablets: A Manageable Risk
QTc Prolongation in Methadone Maintenance: Fact and Fiction
Methadone: Is It Enough?
Download PDF: HeroinAdd8-4.pdf (1.05 MB, 68 pp)

Heroin Addiction and Related Clinical Problems. 2006(Sept), Vol. 8, No. 3

In Memory of Vincent P. Dole
Forty Years of Methadone Maintenance Treatment Around the World; Past, Present and Future
Methadone and Treatment Quality. The EFQM Excellence Model
Treatment of Chronic Hepatitis C Virus Infection in Intravenous Drug Addicts: State of the Art
Download PDF: HeroinAdd8-3.pdf (983 KB, 52 pp)

Heroin Addiction and Related Clinical Problems. 2006(June), Vol. 8, No. 2

Say “Yes” to Methadone and Buprenorphine in Russian Federation
Knowledge and Attitudes of Drug Treatment Professionals Toward HIV Prevention and Care Activities in the Russian Federation
A Low-Value Voucher Contingency Management Programme with Israeli Methadone-Maintained Patients – A Pilot Evaluation Study
Treatment for Hepatitis C in Jail Houses is Doable and Successful: Definitive Data of First National French Study (POPHEC)
Is Heroin Addiction Related to a Dysfunctional Processing of Reward and Hedonism in the Brain? Insights from Neuroimaging Studies
Download PDF: HeroinAdd8-2.pdf (970 KB, 60 pp)

Heroin Addiction and Related Clinical Problems. 2006(March), Vol. 8, No. 1

Necessity of a World Federation of Health Organizations Providing Opiate Agonist Therapy for Heroin Addicts
Heroin Dependence in the Russian Federation: The Current Situation
No Intrauterine Growth Retardation in Babies of Mothers Stabilized on Methadone Before Conception and Throughout Their Pregnancies
Effectiveness of Buprenorphine in Double Diagnosed Patients. Buprenorphine as a Psychotropic Drug
Download PDF: HeroinAdd8-1.pdf (918 KB, 52 pp)

2005

Heroin Addiction and Related Clinical Problems. 2005(Dec), Vol. 7, No. 4

Addiction and Pregnancy
Primary Care Physicians and Addiction Treatment in Germany. Decentralization and Take-home Policy
Psychopathological Disorders in Heroin Addicts and Administration of Risperidone During Rehabilitation
Methadone Reduces the Need for Antipsychotic and Antimanic Agents in Heroin Addicts Hospitalized for Manic and/or Acute Psychotic Episodes
Methadone Serum Concentration and its Relationship to Methadone Dose Revisited
Medical and Social Factors Determining Early Poly-Drug Dependence
Download PDF: HeroinAdd7-4.pdf (1.20 MB, 70 pp)

Heroin Addiction and Related Clinical Problems. 2005(Sept), Vol. 7, No. 3

Psychotherapy for Patients in Methadone Treatment
Buprenorphine High-Dose, Broad Spectrum, Long-term Treatment: A New Clinical Approach to Opiate Alkaloid Dependency
Correlation Between High Methadone Dose and Methadone Blood Levels in Methadone Maintenance Treatment Patients
Addictive Disorders, Bipolar Spectrum, and the Impulsive Link: The Psychopathology of a Self-Regenerating Pathway
Bridging the Preclinical-Clinical Gap
Mortality and Retention of Drug Users in GP Shared Care in Glasgow
Working with the Patient for Optimal Treatment Outcomes in UK General Practice
Download PDF: HeroinAdd7-3.pdf (1.00 MB, 60 pp)

Heroin Addiction and Related Clinical Problems. 2005(June), Vol. 7, No. 2

Methadone Maintenance Treatment and Mood Disturbances: Pharmacological and Psychological Implications
Long-term Treatment for Patients with Severe Mental Illness and Substance Abuse
Good Practice, Good Results. Maintenance Treatment Outcomes in France
The Endogenous Cannabinoid System: Physiological Modulation of Neuronal Activity
Substitution Treatment in European Prisons. A Study of Policies and Practices of Substitution Treatment in Prison in 18 European Countries
Medical Meaning of Psychosocial Issues of Heroin Addiction
Download PDF: HeroinAdd7-2.pdf (1.13 MB, 52 pp)

Heroin Addiction and Related Clinical Problems. 2005(March), Vol. 7, No. 1

Europad 6th Conference, Paris, France, EU
Buprenorphine Induction and Stabilisation in the Treatment of Opiate Dependence
Clinical Significance of Electroencephalographic Abnormalities in Heroin Addicts: Systematic Review
Alcohol Abuse in Heroin Addicts: An Unfolding Metabolic Destiny
Symptomatic Treatment of Opiate Withdrawal Syndrome by Low-dose Buprenorphine in an In-Patient Setting
Open Letter to Physicians and Other Health Care Providers Facing Pain Management During Opioid Agonist Therapy with Methadone
Download PDF: HeroinAdd7-1.pdf (967 KB, 52 pp)

2004

Heroin Addiction and Related Clinical Problems. 2004(Dec), Vol. 6, No. 3

Patient-Treatment Matching and Opioid Addicted Patients: Past Methods and Future Opportunities
Methadone Patients' Sexual Dysfunctions: Clinical and Treatment Issues
Unreported Double Frequency of Heroin Addicts Visiting Psychiatric Services and Addiction Treatment Services
Evaluation of Effectiveness of Drug Treatment Programmes in the Ukraine
Bad Patients or Bad Treatment?
Opiate Dosage Adequacy Scale (ODAS): A Clinical Diagnostic Tool as a Guide to Dosing Decisions
Download PDF: HeroinAdd6-3.pdf (1.20 MB, 54 pp)

Heroin Addiction and Related Clinical Problems. 2004(August), Vol. 6, No. 2

Craving in Opiate, Cocaine and Alcohol Addiction
Clinical Foundations for the Use of Methadone in Jail
Download PDF: HeroinAdd6-2.pdf (2.24 MB, 78 pp)

Heroin Addiction and Related Clinical Problems. 2004(April), Vol. 6, No. 1

Addressing Violence in Methadone Maintenance Treatment
"Vedette" Study and "Tracking" Project; Their Integration and Preliminary Results
Methadone Treatment. Safe Induction Techniques
Naltrexone as Maintenance Therapy for Heroin Addiction: Predictors of Response
Download PDF: HeroinAdd6-1.pdf (1.65 MB, 60 pp)

2003

Heroin Addiction and Related Clinical Problems. 2003(Dec), Vol. 5, No. 3

Understanding the Pathogenesis of Drug Addiction in Order to Implement a Correct Pharmacological Intervention
Structured Motivational Interventions in Methadone Maintenance Treatment
Psychiatric Severity and Treatment Response in Methadone Maintenance Treatment Programmes: New Evidence
Treatment of Prisoners Addicted to Prohibited Drugs in Institutions for Criminal Law Sanctions in Maribor, Slovenia
-Clinical Picture and Treatment of Psycho-organic Syndrome in Drug Addicts
Download PDF: HeroinAdd5-3.pdf (1.97 MB, 60 pp)

Heroin Addiction and Related Clinical Problems. 2003(August), Vol. 5, No. 2

Dual Diagnosis in Heroin Addicts. The Clinical and Therapeutic Aspects
Personality Disorders in Addicted Patients
Mood Disorders in Addicted Patients
Anxiety Disorders in Addicted Patients
Aggression and Violence in Heroin Addicted Patients
Alcoholism in Heroin-Addicted Patients
Methadone Treatment in Dual Diagnosis Patients
Download PDF: HeroinAdd5-2.pdf (2.18 MB, 108 pp)

Heroin Addiction and Related Clinical Problems. 2003(April), Vol. 5, No. 1

The Impact of Methadone Substitution Therapy (MST) on Illicit Drug Use and Drug Abuse-Related Quality of Life: A European Study
When "Enough" is Still Not "Enough". Effectiveness of High-Dose Methadone in the Treatment of Heroin Addiction
The Impact of Continuing Terror and Stress on the Use of Psychoactive Drugs in Israel
Reduction in Self-Reported Nicotine Dependence After Stabilization in Methadone Maintenance Treatment
Liver Cytochrome Overexpression in Human HCV Infection
Download PDF: HeroinAdd5-1.pdf (1.42 MB, 52 pp)

2002

Heroin Addiction and Related Clinical Problems. 2002(Dec), Vol. 4, No. 3

Harm Reduction and Specific Treatments for Heroin Addiction. Different Approaches or Levels of Intervention? An Illness Centered Perspective
Methadone Treatment in Croatia
The Renaissance of Methadone Treatment in America
Methadone and Commonplaces
Methadone Maintenance and HIV Infection
Breast-Feeding for a Methadone-Maintained Mother: A Case Report
Methadone Maintenance Treatments in European Extra-Community Target
Download PDF: HeroinAdd4-3.pdf (1.36 MB, 52 pp)

Heroin Addiction and Related Clinical Problems. 2002(August), Vol. 4, No. 2

Correlation Between Hepatitis C Serostatus and Methadone Dose Requirement in 1,163 Methadone-Maintained Patients
Is Craving for Heroin and Alcohol Related to Low Methadone Dosages in Methadone Maintained Patients?
Clinical Foundations for the Use of Methadone. Italian Consensus Panel on Methadone Treatment
“Manifesto of Barcelona”: Care Programmes for Health Professionals with Mental
Disorders and Addictive Behaviours in Europe
Galicia Document on Problems Related to Addictive Disorders in Europe
5th Conference of The European Opiate Addiction Treatment Association and 2002 “Chimera Award”
Download PDF: HeroinAdd4-2.pdf (556 KB, 52 pp)

Heroin Addiction and Related Clinical Problems. 2002(April), Vol. 4, No. 1

Mortality Among Problem Drug Users in Europe: A Project of the European Monitoring Centre for Drugs and Drug Addiction (EMCDD)
Buprenorphine: Evidence for Effectiveness
1995-2001 Programme Evaluation of the A-Center for Treatment of Addicts Consuming Prohibited Drugs at Maribor, Slovenia
Does Therapeutic Threshold of Methadone Concentration in Plasma Exist?
Treatment Characteristics and Retention in Methadone Maintenance: High and Stable Retention Rates in a Swedish Two-Phase Programme
Download PDF: HeroinAdd4-1.pdf (448 KB, 50 pp)

2001

Heroin Addiction and Related Clinical Problems. 2001(Dec), Vol. 3, No. 2

The Problem of Drug Dependence
Evaluation Survey of a Methadone Treatment Share Care Programme Between a Specialized Clinic and a Network of GPs
Treatments of Substance Users Detainees in La Santé Prison
Intensive Sport and Risk of Heroin Addiction
The Differences Between Heroin Addicts With and Without Comorbidity
Methadone Treatment: Italy vs USA – Methadone Treatment in Europe
Download PDF: HeroinAdd3-2.pdf (1.52 MB, 52 pp)

Heroin Addiction and Related Clinical Problems. 2001(June), Vol. 3, No. 1

The Promise of Opioid Receptor Antagonist Drugs in the Treatment of Neuropsychiatric Disorders
Haematic Concentrations Versus Oral Doses of Methadone. Comparative Assessment of Two Reference Systems During Substitute Therapy in Opiate Addiction
Therapeutic Effects of Paroxetine on the Cocaine Abuse in Heroin Addicts
Methadone Regulations in USA: Comments, Proposal to Adopt New Regulations and Proposed Rule
Articulation of Codeine Treatment and Methadone Maintenance Programs
The Differences Between Inpatients and Outpatients with Illegal Drug Use: Prevalence of Comorbid Mental Disorders
Download PDF: HeroinAdd3-1.pdf (1.20 MB, 48 pp)

2000

Heroin Addiction and Related Clinical Problems. 2000(Dec), Vol. 2, No. 2

Managing Benzodiazepine Withdrawal
Addiction and Methadone: One American's View
An Evaluation Study on Share Care Methadone Treatment Between a Specialized Clinic and a Network of General Practitioners
Opioids and Cannabinoids Abuse Among Bipolar Patients
Pregnant Addict Care in Methadone Treatment Programs
Prohibitionism, a Feasible Way Forward
Hepatitis C Infected Patients and Higher Doses of Methadone
Introducing the European Collaborating Centres in Addiction Studies (ECCAS)
Download PDF: HeroinAdd2-2.pdf (737 KB, 70 pp)

Heroin Addiction and Related Clinical Problems. 2000(June), Vol. 2, No. 1

Women, Pregnancy and Methadone
Sexual Dysfunction Associated with Methadone Maintenance: Treatment with Bromocriptine
Attitudes and Beliefs Towards Methadone of Staff Working in Substance Abuse Treatment
Is Prescribing Higher Doses of Methadone Likely to Promote Elevated Drop-out Rates?
The Pacific Drug Policy Institute and Research Findings That Led to Its Founding
Methadone Treatment: An Interesting Analogy
Take-Home Doses and Compliance with Methadone Maintenance Treatment
Methadone Dose and Retention in Treatment of Heroin Addicts with Bipolar I Disorder Comorbidity, Preliminary Results
Discontinuation Symptoms are Not Addiction/Dependence
Download PDF: HeroinAdd2-1.pdf (545 KB, 60 pp)

1999

Heroin Addiction and Related Clinical Problems. 1999(Dec), Vol. 1, No. 2

Alcohol, Benzodiazepines and Other Drug Use in Heroin Addicts Treated with Methadone. Polyabuse or Undermedication?
What Defines Switzerland’s Drug Policy? Switzerland: Drug Policy of Mountain Dwellers?
Methadone Treatment and Spread of AIDS in Europe in the 1987-1992 Years
Adolescent Narcotism in Russia
The Treatment of Viral Hepatitis in Drug Addicts
General Practitioners and Heroin Addiction. Chronicle of a Medical Practice
Download PDF: HeroinAdd1-2.pdf (290 KB, 46 pp)

Heroin Addiction and Related Clinical Problems. 1999(June), Vol. 1, No. 1

Treating Heroin Addicts, i.e. “Breaking through a Wall of Prejudices”
Heroin Addiction as Normal Illness
Methadone Maintenance Comes of Age
Pharmacokinetics and Pharmacogenetics of Methadone: Clinical Relevance
Integrating Methadone Treatment in the Slovenian Public Health System
Treatment of Opiate Dependency: A Comment
Methadone as a Mood Stabilizer
Download PDF: HeroinAdd1-1.pdf (338 KB, 54 pp)

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