Rx Methadone & Safety

Dosing

Methadone Dosing & Safety in the Treatment of Opioid Addiction
Stewart B. Leavitt, MA, PhD; Editor. Released September 2003.
PDF available here for download <click here…> (312KB, 8pp)

When "Enough" is Not Enough: New Perspectives on Optimal Methadone Dose
Stewart B. Leavitt, MA, PhD, Marc Shinderman, Sarz Maxwell, Chin B. Eap, Phil Paris; Mount Sinai Journal of Medicine, Released in 2000.
PDF available here for download <click here… > (91KB, 8pp)

Clinical Diagnostic Tool for Guiding Methadone Treatment of Opioid Addiction
ODAS - Opiate Dosage Adequacy Scale... from Heroin Addiction & Related Clinical Problems. 2004;6(3)39-49. Distributed with permission of the journal.
PDF available here for download <click here…> (452KB, 12pp)

Cardiac Concerns

Cardiac Considerations During MMT
Stewart B. Leavitt, MA, PhD; Editor & and Mori J. Krantz, MD, FACC. Released October 2003.
PDF file available here for download <click here…> (200KB,6 pp)

Does Methadone Maintenance Treatment Affect Heart Health?
Stewart B. Leavitt, MA, PhD; Editor, Released June 2001.
PDF file available here for download <click here…> (PDF file 88KB, 6pp)

Methadone's Role in Torsade de Pointes Questioned
Stewart B. Leavitt, MA, PhD; Editor. Released September 2002.
PDF file available here for download <click here...> (250KB, 5pp)

Drug Interactions

Methadone-Drug* Interactions – 3rd Edition
(*Medications, illicit drugs, & other substances)
Stewart B. Leavitt, MA, PhD; Editor. Released November 2005.
PDF available here for download <click here…> (660KB, 31pp)

Drugs That Prolong the QT Interval and/or Induce Torsades de Pointes
Raymond L. Woosley, MD. Updated 2006.
HTML file available online <click here…>

Cytochrome P450 Drug Interaction Table
David A. Flockhart, Md, PhD – Division of Clinical Pharmacology Indiana University School of Medicine
PDF available here for download <click here…> (56K, 7pp)

Safety

AT Forum Summer 2007 Newsletter Methadone Overdose in MMT - What to know. How to prevent it. What to do if it happens.

PDF file available here for download <click here…> (8pp)

Methadone Diversion, Abuse, and Misuse: Deaths Increasing at Alarming Rate
From US Department of Justice National Drug Intelligence Center

Released November 2007.

PDF file available here for download <click here…> (20pp)

State Issue Brief on Methadone Overdose Deaths
From National Association of State Alcohol Drug Abuse Directors (NASADAD)

Released November 2007.

PDF file available online <click here…> (23pp)

NASADAD State Issue Brief on Methadone Overdose Report

Methadone Mortality - A Reassessment July 2007
From CSAT/DPT. Released October 2007.

PDF file available here for download <click here…> (426 KB, 48pp)

A National Assessment of Methadone-Associated Mortality: Background Briefing Report
PDF available here for download: CSAT_Methadone_Briefing.pdf (658 KB; 77pp)

Methadone-Associated Mortality: Report of a National Assessment. From CSAT/DPT, 2004.
PDF file available here for download <click here…> (428KB, 60pp)

The Safety of Methadone, LAAM, Buprenorphine
Stewart B. Leavitt, MA, PhD; Editor. Released 2001.
(MS Word Document available here for download <click here…> (48KB, 22pp)
Note: Also see, AT Forum, Spring 2001; 10(2)

Drug Misuse and Dependence: UK Guidelines on Clinical Management
Department of Health (England) and the devolded administrations (2007).
PDF available online <click here…> (137KB, 129pp)

Guide to Treating Drug Emergencies

Drug and Alcohol Abuse: A Clinical Guide to Diagnosis and Treatment; 6th ed., Marc A. Schuckit, MD provides an overview of drug classifications and mechanisms, and covers the pharmacology and mental/physical effects of alcohol, depressants, stimulants, opioids, hallucinogens, cannabis, and more. Most critical, there is an emphasis throughout the book on how to deal with emergency medical problems related to drug abuse, addiction, and overdose.

Schuckit recommends skimming all of the chapters covering the many drug classes. From there, the book can serve as a handbook, kept nearby for easily-accessed advice on dealing with drug-related crises or confirming suspected drug-induced symptomatology appearing in clinical settings.

Drug and Alcohol Abuse: A Clinical Guide to Diagnosis and Treatment; 6th ed. is from Springer. Available online from www.amazon.com ($55.00 + shipping) and at other booksellers.

All URL links noted in documents at this AT Forum website were active at the time of publication. Since the Internet is constantly changing, some linked sites may have moved or become inactive, which is beyond the control of AT Forum.